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Soft Tissue Sarcomas

Because of their similar clinical presentation and biological behavior, it is convenient to consider soft tissue sarcomas as a group. This tumor classification includes histologies such as:

  • fibrosarcoma
  • hemangiopericytoma
  • liposarcoma
  • myxosarcoma
  • undifferentiated sarcoma
  • rhabdomyosarcoma
  • neurofibrosarcomas (schwannomas), and
  • malignant fibrous histiocytoma

Due to the locally-invasive nature of soft tissue sarcomas, surgery must be aggressive and often radical (e.g. amputation) to control the tumor. In human soft tissue sarcomas, the combination of radiation and surgery is a common strategy and results in 80% to 90% local control while achieving acceptable cosmetic results. Accordingly, progressive veterinary cancer Centers often combine radiation therapy and surgery to achieve the highest possible levels of local control. In addition to radiation and surgery, chemotherapy is often used to control distant metastases, particularly for high-grade soft tissue sarcomas.

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